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    HydroEye

DRY EYE SUPPLEMENT

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HydroEye™ 
New! Smaller Capsule Size!

• Unique, patented oral formulation offers dry eye support by providing the necessary nutrients to help maintain a healthy tear film.

• Two softgel capsules taken orally twice daily.
• Contains a proprietary blend of omega 3 and omega 6 fatty acids and other important nutrients.
• Offers long-lasting effectiveness with continued use; results typically experienced within 30-60 days.

(non-prescription supplement) is a unique proprietary blend of omega-6 fatty acids, mucin complex, and nutrient cofactors that addresses the root causes of dry eye syndrome.  This powerful combination helps prevent drying and atrophy of the tear glands while supporting proper tear secretion by promoting the normal structure and function of the lachrymal glands, conjunctival goblet cells, and the mucin network.

Hydroeye™ is formulated with pharmaceutical-grade ingredients in capsule form for maximum potency and bioavailablility, and is free of common allergens, artificial flavors, and colors.

Precautions: Do not use with anticoagulants as this may increase their effect and prolong prothrombin time.  Pregnant or lactating women or individuals with medical conditions should consult a physician before using.  These statements have not been evaluated by the Food and Drug Administration.

Human tears are produced by the lacrimal gland. Tears are distributed by blinking, undergo evaporation from the ocular surface, and drain through the nasolacrimal duct. Dry eye can be caused by an abnormality in any of these processes. For example, Sjogren's syndrome is caused by damage to the lacrimal gland which disables the reflex tear production process. Meibomian gland dysfunction (MGD) alters the oily layer in tears, causing increased evaporation (1).

Essential fatty acids (EFAs) are critical to optimum ocular functioning. EFAs cannot be synthesized by the human body and, therefore, must be obtained from the diet. The omega-6 essential fatty acid, linoleic acid, is of particular importance to dry eye syndrome. The body converts linoleic acid into prostaglandin E1 (PGE1) in the following step-wise sequence: linoleic acid, gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid, prostaglandin E1.

Enzymatic conversion of linoleic acid to PGE1 may be impaired by a wide variety of factors. These include:

•   An insufficiency or imbalance of fatty acid precursors.
•   A deficiency of nutrient conversion factors.
•   Aging.
•   Viral infections.
•   Diabetes.
•   Consumption of foods that are rich in trans-fatty acids and saturated fats.
•   Alcohol.

Black Currant Seed Oil
Black currant seed oil contains both omega-3 and omega-6 fatty acids. These EFAs regulate membrane fluidity and membrane function, serve as precursors to eicosanoids (prostaglandins, thromboxanes, and leukotrienes), exhibit enzyme-like activities, and may be cofactors for enzymes, helping to support healthy tear ducts (2). Research finds statistically significant improvement in overall ocular scores in patients with Sjogren's syndrome treated with linoleic acid and gamma-linolenic acid (GLA) over control groups (3).

Pyridoxal 5-Phosphate
Pyridoxal 5-phosphate is the active form of vitamin B-6. It is necessary for the normal activity of the enzyme delta-6-desaturase, which converts cis-linoleic acid to GLA, and GLA into the precursor of PGE1, dihomo-gamma-linolenic acid. Research using pyridoxal 5-phosphate in combination with essential fatty acids and vitamin C has demonstrated improvement within two to six weeks in two thirds of treated subjects (3).

Ascorbic Acid (Vitamin C) and Ascorbyl Palmitate
Vitamin C is required for the conversion of dihomo-gamma-linolenic acid into prostaglandin E1, and thus is critical for tear production. Ascorbic acid in tears serves an anti-inflammatory role in the eye's defense system (4).

Vitamin A
Vitamin A regulates the proliferation and differentiation of corneal epithelial cells and preserves conjunctival goblet cells. It is required for the synthesis of mucin glycoproteins in the eye. Vitamin A deficiencies negatively affect the lacrimal glands, ocular epithelial cells and conjuctiva. Vitamin A treatment has been shown to support moist, healthy eyes at a cellular level (5,6).

Mucin Complex
The pre-ocular tear film is a complex biochemical fluid produced by the lacrimal glands and epithelial cells on the ocular surface. The symptoms of dry eyes may result from deficiencies and disturbances of the mucin network (7). People who suffer from Sjogren's syndrome have less mucosal epithelial membrane mucin in their conjunctiva than do normal subjects (8).

Magnesium
Magnesium is an essential cofactor in the conversion of linoleic acid into GLA.

Please note: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

HydroEye Formulation

HydroEye is an exclusive formulation designed to provide dry eye relief and support the body's natural tear formation. Like all ScienceBased Health formulations, it is produced in softgel form for maximum absorption and bioavailability.
New! Smaller Capsule Size!

Supplement Facts
Servings Per Container 60
New! Serving Size 2 Capsules
		Amount Per Serving	% Daily Value	New! Total Daily Intake at 4 Capsules Per Day	% Daily  Value
Calories		10		20
Calories from Fat		10		20
Total Fat		1 g	2% *	2 g	4% *
Vitamin A (from retinyl palmitate)		1040 IU	21%	2080 IU	42%
Vitamin C [from calcium ascorbate (Ester-C®)]		90 mg	150%	180 mg	300%
Vitamin B6 (from pyridoxal 5-phosphate)		6.3 mg	315%	12.6 mg	630%
Magnesium (from magnesium sulfate)		20 mg	5%	40 mg	10%
Black Currant Seed Oil		750 mg	†	1500 mg	†
	[15.6% gamma linolenic acid (GLA)]
Mucin Complex (60% mucin)		250 mg	†	500 mg	†
Cod Liver Oil		1.6 mg	†	3.2 mg	†
Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established. * Not a significant source of fat, carbohydrates, or protein

Other Ingredients: Gelatin, glycerin, carob extract, beeswax, lecithin, water, and titanium dioxide.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease/

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